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CREB binds cAMP response elements (CRE) in genomic DNA causing the transcription of various genes including those encoding for steroidogenic enzymes (e.g., aromatase) and cholesterol transport, the precursor substrate for sex steroid synthesis (e.g., steroidogenic acute regulatory protein, StAR)

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Release the skin fold and apply gentle pressure with a clean swab do not rub, as this may affect absorption

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Using the candidate gene approach, Jacovas et al